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Shilin DENG MD ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 323-329 doi: 10.1007/s11684-009-0061-2
关键词: early postmenopausal women bone mineral density exercise effects
null
《医学前沿(英文)》 2017年 第11卷 第3期 页码 378-385 doi: 10.1007/s11684-017-0541-8
The purpose of this study is to characterize a meta-signature of differentially expressed mRNA in chronic kidney disease (CKD) to predict putative microRNA (miRNA) in CKD–mineral bone disorder (CKD–MBD) and confirm the changes in these genes and miRNA expression under uremic conditions by using a cell culture system. PubMed searches using MeSH terms and keywords related to CKD, uremia, and mRNA arrays were conducted. Through a computational analysis, a meta-signature that characterizes the significant intersection of differentially expressed mRNA and expected miRNAs associated with CKD–MBD was determined. Additionally, changes in gene and miRNA expressions under uremic conditions were confirmed with human Saos-2 osteoblast-like cells. A statistically significant mRNA meta-signature of upregulated and downregulated mRNA levels was identified. Furthermore, miRNA expression profiles were inferred, and computational analyses were performed with the imputed microRNA regulation based on weighted ranked expression and putative microRNA targets (IMRE) method to identify miRNAs associated with CKD occurrence. TLR4 and miR-146b levels were significantly associated with CKD–MBD. TLR4 levels were significantly downregulated, whereas pri-miR-146b and miR-146b were upregulated in the presence of uremic toxins in human Saos-2 osteoblast-like cells. Differentially expressed miRNAs associated with CKD-MBD were identified through a computational analysis, and changes in gene and miRNA expressions were confirmed with an in vitro cell culture system.
关键词: chronic kidney disease microRNA mineral bone disorder uremia
Current advances for bone regeneration based on tissue engineering strategies
Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian
《医学前沿(英文)》 2019年 第13卷 第2期 页码 160-188 doi: 10.1007/s11684-018-0629-9
关键词: bone tissue engineering stem cell bone scaffold growth factor bone regeneration
FGF13 suppresses acute myeloid leukemia by regulating bone marrow niches
《医学前沿(英文)》 2022年 第16卷 第6期 页码 896-908 doi: 10.1007/s11684-022-0944-z
关键词: acute myeloid leukemia FGF13 prognosis immune-related genes bone marrow niches
Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 522-526 doi: 10.1007/s11684-016-0485-4
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with continuous or recurrent symptoms. A 42-year-old male patient with intermittent diarrhea accompanied by bloody mucopurulent stools was admitted to our hospital. The diagnosis of UC was confirmed by a combination of laboratory examination, colonoscopy, and histological assay. The patient developed herpes zoster in the hospital, which challenged traditional treatments. Therefore, we performed an autologous bone marrow cells to modulate the immune system with his permission. Autologous bone marrow mononuclear cells were collected and injected locally into the bowel mucosa, and subsequently injected systemically through a peripheral vein. After the patient underwent auto bone marrow mononuclear cells transplantations twice, the patient’s symptoms were alleviated. Furthermore, he recovered from hematochezia, and his hypersensitive C reactive protein decreased. Colonoscopy results showed reduced lesions and decreased areas with bleeding and edema in the sigmoid colon and rectum. No recurrence occurred in the subsequent two years, but long-time monitoring is still necessary for the prophylaxis of colorectal cancer.
关键词: autograft bone marrow stem cells ulcerative colitis cell therapy
Machinability of ultrasonic vibration-assisted micro-grinding in biological bone using nanolubricant
《机械工程前沿(英文)》 2023年 第18卷 第1期 doi: 10.1007/s11465-022-0717-z
关键词: micro-grinding biological bone ultrasonic vibration (UV) nanoparticle jet mist cooling (NJMC) grinding force grinding temperature
Hybrid polymer biomaterials for bone tissue regeneration
Bo Lei, Baolin Guo, Kunal J. Rambhia, Peter X. Ma
《医学前沿(英文)》 2019年 第13卷 第2期 页码 189-201 doi: 10.1007/s11684-018-0664-6
关键词: hybrid polymer bone regeneration tissue engineering biomaterials
Progress of three-dimensional macroporous bioactive glass for bone regeneration
Lijun JI, Yunfeng SI, Ailing LI, Wenjun WANG, Dong QIU, Aiping ZHU
《化学科学与工程前沿(英文)》 2012年 第6卷 第4期 页码 470-483 doi: 10.1007/s11705-012-1217-1
关键词: bioactive glass biopolymer bone regeneration macroporous scaffolds tissue engineering
Thermochemical pretreatment of meat and bone meal and its effect on methane production
Guangxue WU , Zhenhu HU , Mark G. HEALY , Xinmin ZHAN ,
《环境科学与工程前沿(英文)》 2009年 第3卷 第3期 页码 300-306 doi: 10.1007/s11783-009-0031-6
关键词: thermochemical pretreatment meat and bone meal solid reduction solid solubilization methane production potential
矿物浮选吸附平衡模型构建与应用:精准解析矿物 表面离子 / 药剂特征吸附
高雅,付心壮,韩海生,王丽,岳彤,孙伟
《中国工程科学》 2023年 第25卷 第6期 页码 248-258 doi: 10.15302/J-SSCAE-2023.07.020
矿物浮选吸附平衡模型是准确描述矿物浮选过程中所涉及的矿物表面离子 / 药剂吸附平衡的数学模型,首次实现了矿物表面位点与浮选药剂吸附作用亲和性的量化解析。传统浮选理论对矿物表面作用位点缺乏科学描述,难以阐明浮选药剂的吸附作用能力及平衡状态,新浮选药剂体系开发多以“试错法”“复配法”等经验性方法为主。药剂选择性吸附作为浮选作业的核心机制,若不能准确预测其在各矿物表面的吸附行为,将严重限制浮选工艺智能化控制的发展。本文详细论述了矿物浮选吸附平衡模型的构建原理,以赤铁矿 ‒ 石英和一水硬铝石 ‒ 高岭石两个浮选体系为例,通过对少量实验数据的拟合计算,解析出矿物表面活性位点密度Ns、加 / 去质子反应常数Kt1/Kt2、药剂吸附常数Kf等矿物浮选特征常数。将解析的矿物浮选特征常数代入到平衡模型中,预测出各条件下矿物表面电性、离子及浮选药剂的吸附量,通过零电点、实验及测试等方法验证了可靠性,形成了矿物浮选过程预测系统的内核算法。该算法对各条件下每种矿物药剂吸附的初步准确预测,可在一定程度上反映其可浮性趋势,有助于缩短浮选工艺开发周期,对矿物表面药剂吸附机理研究、浮选药剂分子设计、浮选工艺流程优化及智能控制等具有重要意义。
《医学前沿(英文)》 2022年 第16卷 第4期 页码 551-573 doi: 10.1007/s11684-022-0928-z
关键词: HCC bone osteotropism clinical basic researches advances
Dawei ZHANG
《工程管理前沿(英文)》 2019年 第6卷 第4期 页码 557-563 doi: 10.1007/s42524-019-0077-5
关键词: ecological conservation redline development of energy and mineral resources coordinated development
A state-of-the-art review on interfacial behavior between asphalt binder and mineral aggregate
Meng GUO, Yiqiu TAN, Linbing WANG, Yue HOU
《结构与土木工程前沿(英文)》 2018年 第12卷 第2期 页码 248-259 doi: 10.1007/s11709-017-0422-x
关键词: Asphalt binder Mineral aggregate Interfacial behavior Multiscale
FGF23 associated bone diseases
null
《医学前沿(英文)》 2013年 第7卷 第1期 页码 65-80 doi: 10.1007/s11684-013-0254-6
Recently, fibroblast growth factor 23 (FGF23) has sparked widespread interest because of its potential role in regulating phosphate and vitamin D metabolism. In this review, we summarized the FGF superfamily, the mechanism of FGF23 on phosphate and vitamin D metabolism, and the FGF23 related bone disease.
关键词: fibroblast growth factor 23 FGF receptor phosphate metabolism Klotho bone disease
《环境科学与工程前沿(英文)》 2023年 第17卷 第11期 doi: 10.1007/s11783-023-1734-9
● Photochemical conversion of chlorobenzene (CB) on α-Fe2O3 was evaluated.
关键词: Photochemical conversion Chlorobenzene α-Fe2O3 PCDD/Fs Mineral particulate
标题 作者 时间 类型 操作
Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial
Shilin DENG MD ,
期刊论文
Identification of differentially expressed miRNAs associated with chronic kidney disease–mineral bone
null
期刊论文
Current advances for bone regeneration based on tissue engineering strategies
Rui Shi, Yuelong Huang, Chi Ma, Chengai Wu, Wei Tian
期刊论文
Autologous bone marrow stem cell transplantation for the treatment of ulcerative colitis complicated
null
期刊论文
Machinability of ultrasonic vibration-assisted micro-grinding in biological bone using nanolubricant
期刊论文
Hybrid polymer biomaterials for bone tissue regeneration
Bo Lei, Baolin Guo, Kunal J. Rambhia, Peter X. Ma
期刊论文
Progress of three-dimensional macroporous bioactive glass for bone regeneration
Lijun JI, Yunfeng SI, Ailing LI, Wenjun WANG, Dong QIU, Aiping ZHU
期刊论文
Thermochemical pretreatment of meat and bone meal and its effect on methane production
Guangxue WU , Zhenhu HU , Mark G. HEALY , Xinmin ZHAN ,
期刊论文
Bone metastasis of hepatocellular carcinoma: facts and hopes from clinical and translational perspectives
期刊论文
Relationship between the development of energy and mineral resources and ecological conservation redline
Dawei ZHANG
期刊论文
A state-of-the-art review on interfacial behavior between asphalt binder and mineral aggregate
Meng GUO, Yiqiu TAN, Linbing WANG, Yue HOU
期刊论文